ABSTRACT
Objective@#To understand relationship between health literacy and health seeking behavior of undergraduate students in Shandong Province.@*Methods@#A total of 1 460 undergraduate students from three universities in Shandong Province were selected through stratified random sampling method and received a questionnaire survey. Data were analyzed by one-way ANOVA, Chi-square test and regression analysis.@*Results@#The proportion of students with basic health literacy was 64.4% (41.37±10.34). The proportion of students with basic knowledge and concept, healthy lifestyle and behavior, and basic skills was 49.6% (16.28±4.58), 70.3% (17.24±4.99) and 83.7% (7.85±1.58), respectively. About 28.1% of undergraduate students reported delay in seeking medical treatment, 71.9% reported prompt in seeking medical treatment, and 24.2% preferred to seek medical treatment in primary medical institutions, 45.5% secondary hospital and 30.3% tertiary hospital. Grade, major, the ability to gather and understand health information was the main factors affecting health literacy. Major and health information screening ability was the main factors affecting health seeking behavior. Grade, major, origin, the awareness and gathering of health information was the main factors affecting the choose of medical institutions(P<0.05). Basic knowledge and concept, basic skills and health literacy was positively correlated with the timing of health seeking behavior, while basic knowledge and concept, healthy lifestyle and behavior, and basic skills might give information on students’ preference on selecting a medical institution.@*Conclusion@#Attention should be paid to the cultivation of health information literacy. An integrated health education and health promotion model of "family-community-hospital-university" should be established.
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the inhibitory effect of recombinant adenovirus carrying human endostatin gene (Ad-endo) on the growth of human pancreatic carcinoma xenograft in nude mice.</p><p><b>METHODS</b>The expression of endostatin in human pancreatic carcinoma Capan-2 cells was examined by RT-PCR after infection with Ad-endo. The supernatants of Capan-2 cells were collected after 48 h of infection with Ad-endo as the conditioned medium for human umbilical vein endothelial cells (HUVECs), whose proliferation in vitro was assayed. Capan-2 cell xenografts were established to determine the antitumoral effects of Ad-endo in vivo. The intratumoral microvessel density (MVD) was evaluated using CD31 staining.</p><p><b>RESULTS</b>The expression of endostatin gene was detected by PT-PCR in infected Capan-2 cells. The conditioned medium from Ad-endo-infected cells significantly inhibited HUVEC proliferation (P<0.05). Ad-endo significantly suppressed the growth of Capan-2 tumor xenografts in nude mice (P<0.05), and the MVD decreased significantly in the treated tumor (P<0.05) as compared with that in the control group.</p><p><b>CONCLUSION</b>Adenovirus carrying human endostatin gene produces inhibitory effects on the growth of human pancreatic carcinoma tumors in nude mice.</p>
Subject(s)
Animals , Humans , Mice , Adenoviridae , Genetics , Metabolism , Angiogenesis Inhibitors , Metabolism , Pharmacology , Endostatins , Genetics , Mice, Inbred BALB C , Mice, Nude , Neoplasm Transplantation , Neovascularization, Pathologic , Genetics , Pancreatic Neoplasms , Pathology , Therapeutics , Recombinant Proteins , Genetics , PharmacologyABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and toxicity of the combined therapy with oxaliplatin and capecitabine (XELOX) in patients with advanced or recurrent gastric cancer.</p><p><b>METHODS</b>Forty-one patients with previously untreated advanced or recurrent gastric cancer received intravenous infusion of oxaliplatin at the dose of 130 mg/m(2) on day 1 and oral administration of capecitabine at 1000 mg/m(2) twice a day on days 1-14. The chemotherapy was repeated every 2 weeks for a median of 4 cycles.</p><p><b>RESULTS</b>Two of 41 patients achieved a complete response, and 15 had partial responses, with an overall response rate of 41.5%. Stable disease was observed in 11 patients and progressive disease in 9. The median time to progression and overall survival was 6.2 months and 11.8 months. All the 41 patients were evaluated for toxicity according to NCI criteria, 4 showed grade 3-4 neural toxicity, 4 had hematological toxicity and 3 had hand-foot syndrome.</p><p><b>CONCLUSION</b>The XELOX regimen shows good efficacy with an acceptable toxicity profile in advanced or recurrent gastric cancer patient.</p>